A wagon train heading west across the great desert runs out of water, and is attacked by Indians. One man -- their last hope -- is sent out to find water.
Adonese is returning home from seeing the woman he is courting, and he is driving around a corner when his car accidentally brushes against the tramp 'Faithful' and knocks him over. Feeling sorry for him, Adonese helps him up and buys him a new suit of clothes. The naively innocent Faithful reads too much into this gesture, and he begins to follow his benefactor everywhere, expecting to receive future gifts.
Ramona, a young girl growing up on her adoptive mother's rancho in California, falls in love with the Indian lad Alessandro. When Ramona is denied permission to marry Alessandro, the two lovers elope, only to find a life of great hardship and unhappiness amidst the bigotry and greed of the white landowners.